Description
CELL MEMBRANE THERAPY: CLINICAL PRACTICE IN BRAIN, LIVER AND CARDIOVASCULAR DISEASES
A book by Prof. Dr. Mike Chan and Prof. Dr. Yuriy Nalapko
Published by Matador, Troubador.co.uk, London – Medical Research: ISBN 978 1838592 509
Table of Content
Foreword | xi |
Preface | xii |
Abbreviations | xv |
CHAPTER 1 | 1 |
From Cell to Molecule | 1 |
1.1.Cellular membrane and its structure | 1 |
1.2. Essential phospholipids | 2 |
Chemical structure and types of phospholipids | 2 |
Cholesterol | 4 |
Choline | 4 |
Acetylcholine | 5 |
CDP-choline | 5 |
1.3. Biosynthesis of phospholipids | 6 |
Phosphatidylcholine | 6 |
Phosphatidylethanolamine | 7 |
Sphingomyelin (SM) | 7 |
CHAPTER 2 | 8 |
Phosphatidylcholine in a Healthy Body | 8 |
2.1. Central nervous system | 8 |
2.2. Cardiovascular system. Atherosclerosis and inflammation | 10 |
Autoimmunity and cholesterol homeostasis | 13 |
2.3. Immune system | 14 |
Phospholipids and immune cell proliferation and migration | 14 |
Infections can stimulate atherosclerosis | 15 |
Targeting cholesterol and inflammation | 16 |
Anti-inflammatory effect of phosphatidylcholine | 16 |
CHAPTER 3 | 19 |
Phosphatidylcholine: From Nature to Medicine | 19 |
3.1. Manufacturing | 19 |
3.2. Natural sources of phosphatidylcholine | 20 |
3.3. Non-medical functional properties of phosphatidylcholine | 20 |
3.4. Brief history of phosphatidylcholine use in medicine | 21 |
Essential phospholipids / polyenylphosphatidylcholine | 23 |
Deoxycholine | 24 |
Pharmacokinetics of exogenous phosphatidylcholine | 24 |
CHAPTER 4 | 25 |
Phosphatidylcholine at Clinical Practice | 25 |
4.1. Neurodegenerative diseases 25 | 25 |
Alzheimer’s disease | 25 |
Parkinson’s disease | 27 |
4.2. Brain stroke and central nervous system injury | 28 |
Traumatic brain injury | 28 |
Spinal cord injury | 30 |
4.3. Liver diseases and diabetes | 30 |
Non-alcoholic fatty liver disease | 31 |
Overview of reviewed clinical studies regarding the influence of administration of PC on FLD (by K-J Gundermann et al., 2016) | 32 |
Alcoholic liver disease | 36 |
Acute viral hepatitis | 38 |
Chronic hepatitis | 39 |
Cirrhosis of the liver and hepatic coma | 40 |
Toxic liver damage | 41 |
Diabetes | 41 |
4.4. Atherosclerosis | 42 |
4.5. Ophthalmology | 43 |
4.5. Ophthalmology | 43 |
Retinal degeneration | 43 |
Amblyopia and non-arteritic ischemic optic neuropathy | 44 |
Glaucoma | 44 |
4.6. Infections | 46 |
4.7. Acute respiratory distress syndrome | 48 |
CHAPTER 5 | 51 |
Practical Aspects of PlaqX | 51 |
Indications for PlaqX therapy | 54 |
Contraindications | 55 |
Safety | 55 |
Adverse drug reactions | 56 |
Forms | 56 |
Protocols | 56 |
Drug interactions | 57 |
Case Studies | 57 |
Alchoholic Fatty Liver Disease | 63 |
Summary | 65 |
References | 67 |